The invention relates to an intelligent protection power distribution cabinet, and belongs to the technical field of intelligent protection power distribution cabinet structures. The intelligent protection power distribution cabinet comprises a plurality of temperature sensors installed in an electric power cabinet. The plurality of temperature sensors are respectively arranged on a switch contact, a jointing clamp and a cable outer layer; the top of the electric power cabinet is provided with a plurality of smoke sensors. A plurality of humidity sensors are mounted on the rear wall of the electric power cabinet; a vibration inclination angle sensor is installed on the side wall of the electric power cabinet. A fire extinguisher is further mounted on the side wall of the electric power cabinet; a plurality of nozzles are arranged on the fire extinguisher; the nozzles are arranged on top of electrical components, an energy storage spring is mounted on a handle of the fire extinguisher;one end of the energy storage spring is connected with the handle, and the other end is mounted on the electric power cabinet; an electromagnetic microswitch used in cooperation with the energy storage spring is installed on the handle, the temperature sensors, the smoke sensors, the humidity sensors and the inclination angle sensor are all connected with a controller arranged in the electric power cabinet, and the controller sends collected information to a monitoring center and a mobile phone APP of a person in charge of equipment through a network. The intelligent protection power distribution cabinet is long in service life and high in safety coefficient.