Multi-use optical data, powerline data, and a ground power interface for airplane factory automation are provided. Specifically, a method for communicating data between a vehicle and a ground system comprises receiving, by a vehicle bus multiplexer, the data via a plurality of vehicle data buses from an onboard system. The method further comprises multiplexing, by the vehicle bus multiplexer, thedata into at least one data path of a multi-use power interface. Also, the method comprises transmitting, by the multi-use power interface via at least one data path, the data from the vehicle bus multiplexer to a ground bus multiplexer associated with the ground system. In addition, the method comprises demultiplexing, by the ground bus multiplexer, the data from at least one data path of the multi-use power interface into a plurality of ground data buses associated with the ground system. Further, the method comprises transmitting, by the ground bus multiplexer, the data via the plurality ofground data buses to the ground system.