The invention relates to the technical field of tobacco planting, in particular to a tobacco disease control method. The tobacco disease control method comprises the following steps that (a), tobaccois subjected to seedling raising in a medium containing a microbial agent; (b), transplanting is conducted in the growth time, the microbial agent is sprayed to tobacco seedlings before transplanting;c), 25-30 days after the tobacco is transplanted, a mixture of the medium containing the microbial agent and tobacco fertilizer is applied to the roots of the tobacco, wherein the active ingredientsof the microbial agent comprise bacillus subtilis and pseudomonas fluorescens. Accordingly, in the tobacco seedling raising stage and after transplantation, the mixed bacteria agent of the bacillus subtilis and the pseudomonas fluorescens is applied, diseases such as blackleg and bacterial wilt of the tobacco can be effectively controlled through different application time and application methods,and the tobacco incidence is lowered.