The invention discloses a device and method for styrene refining and activated aluminum oxide regeneration. The device comprises an adsorption tower, a refined styrene storage tank, a heating system,a crude styrene storage tank and a nitrogen storage tank. The device provided by the invention realizes completion of styrene refining and activated aluminum oxide nitrogen purging regeneration in a same closed window, reduces the probability that styrene is in contact with the outside, reduces the probability that the styrene is polluted, simplifies an activated aluminum oxide regeneration process, solves the problem that in the prior art, a styrene refining process and the activated aluminum oxide regeneration process need to be independently carried out, improves the styrene refining efficiency, saves the energy, and reduces pollutant emission.