The invention is suitable for the technical field of power grid optimization setting, and provides a high-reliability power grid optimization configuration method, a terminal device and a storage medium, and the method comprises the steps: obtaining the annual value investment cost of a fan, a photovoltaic unit, a super capacitor, a storage battery and a diesel generator in a high-reliability power grid, and constructing a target function; obtaining constraint conditions of independent operation of the high-reliability power grid; and solving an optimal configuration result of the high-reliability power grid according to the target function and the constraint condition. The embodiment of the invention provides a high-reliability power grid optimization configuration method. According to the method, the objective function related to the equal-year-value investment cost is established through the equal-year-value investment cost of each device or unit in the high-reliability power grid,then the optimal configuration data of the high-reliability power grid is obtained through calculation of the objective function, and a decision basis is provided for planning of the high-reliabilitypower grid.