The invention relates to the technical field of optical disc storage, and discloses a replaceable disc cage device and an optical disc storage box. The replaceable disc cage device comprises an optical disc rack and a fixing device. A plurality of disc grooves are uniformly distributed in the optical disc rack in a central radial shape, and the optical discs are vertically placed in the disc grooves. The fixing device is detachably connected with the optical disc holder, and a top cover is arranged on the side, away from the optical disc holder, of the fixing device and can abut against the side edge of the optical disc so as to fix the optical disc. The invention further discloses an optical disc storage box comprising the replaceable disc cage device. The compact disc holder is used forstoring compact discs, and is high in integration level and large in storage capacity. The compact discs are vertically placed in the disc grooves of the compact disc rack, so that the storage requirement that the compact discs need to be vertically stored in the national industry standard is met. The fixing device is detachably connected with the optical disc rack, so that the optical disc is convenient to take and place. The top cover on the fixing device can abut against the side edge of the optical disc, scattering and toppling of the optical disc in the transportation process are avoided,and stable storage of the optical disc is achieved.