The invention discloses a high-efficiency antibacterial fiber and a manufacturing method thereof. The method mainly comprises the three steps of antibacterial masterbatch preparation, antibacterial fiber preparation and antibacterial FDY cellosilk preparation. Accordingly, by means of the fact that a nanometer silver-carrying molecular sieve has the advantages of being small in crystal size, larger in specific surface area, high in silver-carrying amount and the like, the high-efficiency antibacterial fiber is prepared, the content of an antibacterial agent in the fiber is less than or equal to 1%o, and the sterilization rate reaches 99% or above; after repeated washing, the antibacterial effect is not obviously declined, in the antibacterial fiber preparation process, an organic solvent is not needed, the silver-carrying nanometer molecular sieve is prepared through a one-pot method, no organic template is needed, the process is simple, the cost is low, and environmental friendlinessis achieved.