The invention provides a comprehensive energy system optimization operation model considering network constraints, and belongs to the field of energy system analysis. According to the model, a comprehensive energy system optimization operation model taking a power system, a fuel gas supply system and a regional heat supply system as main bodies is established; the model aims at minimizing the operation cost of the comprehensive energy system, considers the characteristic constraints of a power network, a gas network and a thermal network, can guarantee the energy supply and demand balance andnetwork operation safety of the comprehensive energy system, and has practical value and guiding significance for the economic and safe operation of the comprehensive energy system.