The invention discloses a resin separation and purification method for grape polyphenols that belongs to the technical field of food industry. According to the method, an alkaline solution is firstlyused to extract wine liquor to obtain a polyphenol alkaline extract. Then, by using NKA-9 or HPD600 macroporous resin, the polyphenol component in the alkaline extract is adsorbed. Finally, ethanol isrecovered to recover grapes phenol. According to the method, full use of the waste (wine mud) produced in the wine making process of grapes is made, which is beneficial to the full utilization of waste resources in the wine industry. The extraction method has mild conditions and high extraction efficiency. By reducing the extraction steps and time of polyphenols, the time and frequency of polyphenol exposure to the air is reduced, and the reducing activity of polyphenol components is protected. Resin materials can be reused after regeneration, reducing extraction costs. In addition, only a low-concentration NaOH solution is used in the extraction process, and no other organic solvents, inorganic acids, or color-protecting agents are used. At the same time, only ethanol is used in the polyphenol adsorption and purification process, so this method is a safe, environmentally-friendly and efficient liquor Extraction of polyphenols.