The invention discloses a partition-positioning liquid leakage detection system and method. In the partition-positioning liquid leakage detection system, two same induction lines are arranged in parallel, a first diode is arranged on a first induction line and is used for partitioning, a reverse second diode is arranged at a connection position of the two induction lines, detection nodes are arranged at positions, corresponding to the two induction lines arranged in parallel, of two end points of the partition, each detection node is connected with a constant flow source and a reference sourceby a dual-control switch, and the guidance direction of the dual-control switch of the detection node is controlled to acquire a voltage of the detection node. By the partition-positioning liquid leakage detection system, whether liquid leakage occurs in an integral wiring region can be detected, a special region where the liquid leakage occurs (a first region or a second region or the two regions occur) and a special position of the liquid leakage can be detected, liquid leakage detection of the two regions are independently performed and are not affected with each other, and the partition-positioning liquid leakage detection system is suitable for liquid leakage detection of the two regions far away from each other at great distance, particularly can be used for detecting the situationthat liquid leakage occurs in both of the two regions and is high in applicability.