The invention relates to the technical field of optical experiment platforms, particularly to an optical experiment platform with an anti-interference device. The optical experiment platform comprisesan optical experiment platform body. A storage groove is formed in the surface of the optical experiment platform body; and a sealing plate is in butt joint with the interior of the storage groove. Atelescopic rod is arranged on the bottom surface of the sealing plate and is inserted into a sleeve; and the sleeve is fixed to the bottom surface of the optical experiment platform body. The opticalexperiment platform has the following beneficial effects: an annular operation hole is formed in a transparent shielding cover, so that the operator can extend hands into the transparent shielding cover to test a workpiece at all angles around the optical experiment platform; a flexible bush sleeves the arm of the operator by cooperating with a closing cloth sleeve and a loosening belt to preventexternal air entrance; and when the platform is in use, a magic male paste arranged on the surface of a connecting plate is adhered to the surface of a magic female paste and then the folded flexiblebush is inserted into the loosening belt after being folded into one part, so that the operation hole is sealed.