The invention discloses a grouting pressure simulation method and device based on partition equivalent grouting pressure vectors. The method comprises: dividing a plurality of grouting areas accordingto the elevation of a grouting section and the inclination angle of a grouting hole; setting a sensitivity coefficient of the grouting area according to the lithology of the grouting area and a grouting construction arrangement condition; and according to the grouting area and the sensitivity coefficient of the grouting area, establishing a partition equivalent grouting pressure vector model, andthe expression of the partition equivalent grouting pressure vector being as follows: the partition equivalent grouting pressure vector model being used for simulating complex distribution of grouting pressure in a fracture network. The technical problem that engineering construction cannot be guided by truly simulating actual grouting pressure through a numerical method is solved.