The invention belongs to the field of anesthetics, and particularly relates to a compound anesthetic and a preparation method thereof. The compound anesthetic is prepared from the raw materials: propofol, methyleugenol, citric acid, menthol ice, herba cladostachvdis, radix paeoniae rubra, ethanol, lecithin and water through extraction and mixing of effective ingredients. The compound anesthetic has good anesthetic and analgesic effects and is small in side effect, and the preparation method is simple and easy to implement.