The present application relates to an antibody, and an antigen binding fragment or variant thereof. The antibody and antigen binding fragment or variant thereof have one or more properties selected from a group consisting of properties: 1) the antibody and antigen binding fragment or variant thereof are capable of being bound to an AXL protein at a KD value of 1x10<-8> M or below; 2) the antibodyand antigen binding fragment or variant thereof can specifically recognize the AXL protein expressed on the cell surface; and 3) the antibody and antigen binding fragment or variant thereof can be mediated and internalized after being bound to the AXL protein expressed on the cell surface. The antibody of the invention can also be used to construct immunoconjugates. Both the antibody and the immunoconjugates can inhibit the proliferation of tumor cells.