The invention relates to a self-cleaning anti-scaling anti-wax precipitation polyolefin pipe, and a preparation method and application thereof. The polyolefin pipe comprises a pipe inner layer and a pipe outer layer; the material of the pipe inner layer is a blended material of a polyolefin modified material and a matrix polyolefin material; the material of the pipe outer layer is a polyolefin material; the preparation method for the polyolefin pipe comprises the following steps of: (1) blending the fluorine-containing group polyolefin modified material and the matrix polyolefin material to obtain a blended material; and (2) performing double-layer co-extruding on the blended material and the polyolefin material to obtain an anti-scaling anti-wax precipitation polyolefin pipe, wherein thepolyolefin pipe can be used for preparing an inner pipe of a steel wire wound pipe. Compared with the prior art, the surface energy of the inner wall of a pipeline is reduced by introducing a fluorine-containing group chain segment, so that the pipeline has the functions of preventing scaling and wax precipitation; in addition, the introduction of the fluorine-containing group is also beneficial to improving the high temperature resistance and the corrosion resistance of the pipeline; and therefore, the polyolefin pipe has a broad application prospect.