The invention provides a heat exchange assembly and air conditioning equipment with the heat exchange assembly. The heat exchange assembly comprises an air duct, a cross flow wind wheel and a heat exchange structure, wherein the air duct comprises a first volute and a volute tongue arranged on the first volute, and the air duct is provided with an air inlet and an air outlet; the cross flow wind wheel is arranged in the air duct; the heat exchange structure is arranged on the first volute, the heat exchange structure is at least partly opposite to the air outlet, airflow is led into the air duct through the air inlet by the cross flow wind wheel, the airflow in the air duct is blown to the heat exchange structure through the air outlet, and the airflow is discharged out of heat exchange assembly after heat exchanging between the airflow and the heat exchange structure is completed; and the first volute and the volute tongue are integrally formed. According to the heat exchange assemblyand the air conditioning equipment, the problem that in the prior art, disassembly and assembly of an air duct are tedious and complex, so that the labor intensity of workers is increased is effectively solved.