The invention discloses a foreign matter prevention management system for a nuclear power plant maintenance area. The system comprises a gate machine, a tool and instrument inspection system, a network switch, a background server and a worker operation table; the gate machine and the tool and instrument inspection system are connected to the background server and the worker operation table throughthe network switch. The gate machine comprises a gate and face recognition equipment. The tool and instrument inspection system comprises a first QR code scanner; when the tool and instrument inspection system is used, the first QR code scanner scans a QR code of an admission person to enter a tool registration mode, and a worker registers tools carried by a admission person through the worker operation table and binds tool registration information with the personal information of the admission person. The face information of admission personnel is collected through face recognition equipment; after pairing succeeds through the background server, the background server controls a gate to be opened. According to the invention, the personnel/article passing efficiency and the information recording accuracy are improved, the fine management of articles and personnel is realized, and the management and control quality is improved.