The invention discloses a multi-agent and information fusion method for large complex structure damage diagnosis, and relates to the technical field of multi-agent and information fusion methods. Themulti-agent and information fusion method for large complex structure damage diagnosis comprises four steps. After the technical scheme is adopted, the multi-agent and information fusion method has the advantages of being reasonable in the design, effectively improving the accuracy and credibility of processing results of the sensing main bodies, the signal processing main body, the damage diagnosis main body and the decision-making-level main body, carrying out conflict resolution on inconsistent diagnosis results, and finally, reasonably and effectively diagnosing and evaluating the damage state of a large complex structure.