The invention relates to a resource allocation method and device, equipment and a storage medium. The method comprises the following steps: acquiring the required number of resource blocks when targetuser equipment UE transmits uplink data; the quantity is determined according to requirements, searching a resource block of which the interference level satisfies a low level condition and is not allocated to other UE in the target frequency domain range, obtaining a set of target resource blocks, the target resource block set is allocated to the target UE; wherein the target resource block setis used for the target UE to perform uplink data transmission based on the target resource block set; when the target UE carries out uplink data transmission; according to the method, the resource blocks of which the interference levels meet the low-level condition are allocated to the target UE for uplink data transmission according to the required number of the resource blocks of the target UE,so that the situation that the resource blocks of which the interference levels are too high are used for uplink data transmission is avoided, and the problem of high bit error rate in the uplink datatransmission process is further avoided.