The invention provides a fluorine-containing self-polishing resin-based ultra-smooth coating material preparation method, which comprises: 1, carrying out a reaction on a fluorine-containing acrylatemonomer, a carboxyl-containing acrylic acid monomer, methyl methacrylate and ethyl acrylate according to a total weight ratio of 5-45:10-55:5-15:10-30 at a temperature of 80 DEG C for 6 h to synthesize a resin matrix; and 2, carrying out a reaction on the obtained resin matrix and pyridine triphenylborane according to a weight ratio of 70-90:5-30 for 4 h at a temperature of 90 DEG C. According tothe invention, based on the self-polishing effect of the resin matrix, the distance between the lubricating oil seeping and the surface of the coating is not increased so as to ensure the constant seeping speed of the lubricating oil; after the lubricating oil in the coating is used up, the coating resin matrix can still prevent fouling organisms from being attached to the substrate through the self-polishing effect; and the prepared coating solves the problem of coating failure caused by easy loss of the lubricating oil, and is an environmentally-friendly long-acting antifouling coating.