The invention discloses a construction method combining a cast-in-situ cylinder structure with a fabricated structure. The construction method is mainly used in the field of constructional engineeringand high-rise housing structure construction and high in construction speed and also ensures the overall rigidity of a building. The construction method comprises the following steps: 1, at first, utilizing a slip-form construction technology to construct the cast-in-situ cylinder part to the third-floor topping elevation; 2, carrying out hoisting and assembling operation on the first-floor and second-floor fabricated framework structures; 3, penetrating vertical reinforcement cage through a plurality of U-shaped rebars of first-floor and second-floor framed girders A, and placing the bottomof the vertical reinforcement cage to the foundation top surface of the cylinder; 4, filling concrete in cavities of vertical through holes to enable the cast-in-place concrete to fill th vertical through holes and the cavities of a plurality of horizontal holes, after the concrete reaches certain strength, carrying out slip-form construction on the third-floor and fourth-layer cylinders; the construction method of other floors can be done in the same manner; pre-embedding a plurality of U-shaped rebars in the combined end sockets of the framed girders A and the cylinders; and the positions ofthe U-shaped rebars are in one-to-one correspondence with those of horizontal holes.