The invention discloses a relay protection setting calculation method and device based on a micro-service architecture, and the method comprises the steps: detecting the current operation performanceand current state of each micro-service of the micro-service architecture, so as to monitor whether each service operates normally or not; if not, searching for the service running abnormally, and restarting the service running abnormally; and if yes, determining operation parameters according to a preset demand, providing a corresponding visual interface for the user based on the subscription management service and the authority management service, configuring a corresponding function based on the granular service of each function, and generating a setting calculation result according to thesubscribed service. According to the method provided by the embodiment of the invention, logic independence of relay protection setting computing system functions, simplification of an operating system and flexible subscription of each functional module are realized on the basis of a virtualized micro-service component and a unified micro-system platform.