The invention provides a tough and adherent wet tissue hydrogel dressing box. The tough and adherent wet tissue hydrogel dressing box comprises two components stored separately, wherein the componentA is hydrogel formed by crosslinking sodium alginate and acrylamide, and the component B is a coupling solution prepared from the raw materials of a coupling agent, a linking agent and a buffer solution. The hydrogel dressing box is convenient to use. By adding the component B, the adhesive performance of a hydrogel dressing is significantly improved, and the hydrogel dressing has high adhesion strength to the skin surface and the surface of wet tissue in the body, is not prone to falling off and meets clinical demand. Meanwhile, the hydrogel dressing has excellent mechanical properties and biocompatibility and can be degraded. In addition, the dressing has the water content of up to 86%, can be loaded with a large number of drugs, can provide a good environment for tissue recovery and promote tissue healing. The tough and adherent wet tissue hydrogel dressing box not only solves the problems that traditional dressings have poor treatment effects of wounds and cannot be degraded and the like, but also solves the problem of poor adhesion performance of novel dressings, can further be applied to tissue in vivo, and has broad application prospects.