The invention relates to the technical field of textile machinery, in particular to a card clothing comb pressing device for a carding machine. A surface of a pressing base is penetratingly provided with an axial groove, two sides of the axial groove are provided with steps, the step on each side is provided with a plurality of clamping grooves, the steps between the clamping grooves are providedwith threaded holes, and screw rods are arranged in the threaded holes. A card clothing comb with teeth downwards is placed in the axial groove, a comb shaft is placed on the card clothing comb, pressure plates are put on the comb shaft and connected with the screw rods through pressure plate holes, the screw rods are provided with nuts, and the nuts can be rotated to enable the pressure plates topress the card clothing comb on the surface of the comb shaft. The card clothing comb is fixed to the comb shaft by fixing clamps on two sides of the card clothing comb at each clamping groove. The fixing clamps are V-shaped spring clamps with two lower sides in symmetrical sharp hook structures, and the card clothing comb is fixed to the comb shaft when teeth of the card clothing comb are hookedby the sharp hook structures. The card clothing comb pressing device has advantages that surface smoothness of the card clothing comb is realized, simplicity and convenience in mounting are achieved,labor intensity of workers is relieved, production efficiency of enterprises is effectively improved, and economic benefits of the enterprises are effectively increased.