The invention provides a safe wireless radio frequency monitoring medical system, which is characterized in that a plurality of tag readers are reasonably arranged in an indoor rectangular space to acquire wireless radio frequency tags carried by a patient, and a transit server realizes accurate positioning according to a signal intensity value; meanwhile, the gateway equipment realizes asymmetricencryption of the transmission data in a proxy encryption mode; the safety of data comprehensive analysis of the information management server is ensured; different noise simulation network attack models are constructed for different classifications; the noise simulation network attack model is trained by using the real network attack flow, and after the network attack models of different classifications are trained, the noise simulation network attack model is alternately accessed to the machine learning module to serve as a simulation attack source of the machine learning module so as to help to improve the detection capability of the machine learning module and better serve patients in a building.