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发明公开
CN110678755A 基于唾液白介素-1β以及MMP-9的轻度或重度牙周炎的诊断 审中-实审

基于唾液白介素-1β以及MMP-9的轻度或重度牙周炎的诊断
摘要：
公开了一种用于评估患有牙周炎的人类患者是否患有轻度牙周炎或重度牙周炎的体外方法。该方法基于确定针对三种生物标志物蛋白质的选择的见解。因此，在患有牙周炎的患者的唾液样本中，以下蛋白质的浓度被测量：白介素-1β(IL-1β)、基质金属蛋白酶-9(MMP-9)、以及以下项中的至少一种蛋白质：白介素-6(IL-6)和基质金属蛋白酶-3(MMP-3)。基于所测量的浓度，确定反映针对所述蛋白质的联合浓度的值。将该值与阈值进行比较，该阈值以相同的方式反映与重度牙周炎相关联的联合浓度。该比较允许评估检测值是否是所述患者存在重度牙周炎或轻度牙周炎的指示。从而，典型地，反映联合浓度的测试值低于由阈值所反映的联合浓度是所述患者存在轻度牙周炎的指示，以及反映联合浓度的测试值处于或高于由阈值所反映的联合浓度是所述患者存在重度牙周炎的指示。
摘要（英）：

Disclosed is an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The method is based on the insight to determine a selection of three biomarker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of the proteins Interleukin-1 beta (IL-1beta), Matrix metalloproteinase-9 (MMP-9) and at least one of the proteins: Interleukin-6 (IL-6), and Matrix metalloproteinase-3 (MMP-3). Based on the concentrations as measured, a value is determined reflecting thejoint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with advanced periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of advanced periodontitis or of mild periodontitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for mild periodontitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for advanced periodontitis in said patient.

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