The invention discloses a synthesis method of a cadmium-metal-organic framework material, and belongs to the technical field of crystalline material preparation. The preparation method comprises the following steps: mixing cadmium nitrate tetrahydrate, 3, 3 ', 5, 5'-biphenyltetracarboxylic acid, N, N-dimethylacetamide and acetic acid, and carrying out ultrasonic treatment to completely dissolve solids; after ultrasonic treatment, transferring an obtained mixed solution into a high-pressure reaction kettle with a polytetrafluoroethylene lining, and the reaction kettle is placed in a drying ovenat the temperature of 80-100 DEG C for constant-temperature reaction for 12-24 h. According to the method, the synthesis time is greatly shortened, the reaction temperature is reduced, the cost is reduced, and industrial application is facilitated.