The invention discloses an integral vibration reduction sleeper wrapped by polyurethane. The sleeper comprises a sleeper body, steps are arranged on two sides of the upper end of the sleeper body; thevibration reduction sleeper further comprises an elastic buckling and pressing plate, a sealing layer, a polyurethane isolation layer, a filling protection layer and a polyurethane elastic layer. Oneend of the elastic buckling and pressing plate is arranged on the step, the sealing layer, the polyurethane isolation layer and the filling protection layer sequentially wrap the two sides of the sleeper body from top to bottom, the polyurethane elastic layer is embedded in the bottom of the sleeper body, and the polyurethane isolation layer, the filling protection layer, the polyurethane elasticlayer and the sleeper body are of a preformed integrated structure. According to the vibration reduction sleeper, the phenomena of sleeper empty hanging, ballast bed cement slurry turning and the like caused by construction and vehicle operation can be prevented. The transverse and vertical restraining force is larger, the track gauge keeping capacity is higher, and the vibration reduction effectis further enhanced.