The invention provides a large power grid static security analysis fault screening method based on GPU acceleration. Branch on-off and generator on-off models are established for anticipated faults ofbranch on-off and generator on-off, and the models solved to obtain a workflow and a data flow required by calculation; a fine-grained parallel algorithm for static security analysis fault identification based on GPU acceleration is further designed; and fault lines are obtained by generating active power of lines under various working conditions in batches. The static security analysis fault screening method provided by the invention is relatively high in calculation precision, achieves a great acceleration effect, and meets the requirement for online application.