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发明公开
CN110730670A 基于多抗原提呈系统(MAPS)的金黄色葡萄球菌疫苗、免疫原性组合物以及它们的用途 审中-实审

基于多抗原提呈系统(MAPS)的金黄色葡萄球菌疫苗、免疫原性组合物以及它们的用途
摘要：
本实施方式提供了金黄色葡萄球菌(SA)多抗原提呈系统(MAPS)免疫原性组合物，所述免疫原性组合物包含诱导免疫应答的免疫原性多糖，其中，至少一种金黄色葡萄球菌(SA)肽抗原或多肽抗原通过互补亲和分子缔合至所述免疫原性多糖。在一些实施方式中，所述免疫原性多糖可为来自金黄色葡萄球菌的5型或8型抗原性荚膜多糖，或者为不同的免疫原性荚膜多糖或非荚膜多糖，并且其中，所述蛋白SA抗原或肽SA抗原通过亲和结合对间接连接。本发明的SA-MAPS免疫原性组合物可同时引发针对所述免疫原性多糖以及一种或多种SA抗原的体液免疫应答以及细胞免疫应答这两者。
摘要（英）：

The present embodiments provide for an S. aureus (SA) Multiple Antigen Presenting System (MAPS) immunogenic composition comprising an immunogenic polysaccharide which induces an immune response, whereat least one S. aureus (SA) peptide or polypeptide antigen is associated to the immunogenic polysaccharide by complementary affinity molecules. In some embodiments, the immunogenic polysaccharide canbe an antigenic capsular polysaccharide of a Type 5 or Type 8 from S. aureus, or alternatively, a different immunogenic capsular or noncapsular polysaccharide, and where the protein or peptide SA antigens are indirectly linked via an affinity binding pair. The present SA-MAPS immunogenic compositions can elicit both humoral and cellular immune responses to the immunogenic polysaccharide and one or multiple SA antigens at the same time.

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