The invention belongs to the technical field of healthcare medicine, and relates to a Coral dealbatus and Gynura divaricata compound granule and a preparation method thereof. The granule comprises thefollowing raw materials in parts by weight: 100 to 160 parts of Coral dealbatus, 80 to 120 parts of wolfberry fruit, 10 to 20 parts of raspberry and 30 to 40 parts of Gynura divaricata. The preparation method of the granule comprises the following steps: Coral dealbatus processing, raspberry processing, Gynura divaricata and wolfberry processing and particle preparation. The granule is prepared by scientifically proportioning Coral dealbatus, wolfberry fruit, raspberry and Gynura divaricata, and does not contain any artificial synthetic substance; the preliminary edible research of the nutritional ingredients finds that a diabetic patient can effectively reduce the level of HbA1c after taking the food; and the granule is scientific in compatibility, simple in process, low in cost, easy toobtain nutritional ingredients, good in clinical effect and environmentally-friendly in application, and is suitable for industrial production.