The invention belongs to the technical field of chemical separation processes and equipment, and discloses a separation device for a dividing-wall column and a regulation and control method of the separation device. The device includes the dividing-wall column and a gas flow amplifier, wherein the dividing-wall column mainly comprises a stripping section, a separation plate, a preliminary separation tower, a side extraction section and a rectification section; through the gas flow amplifier A, a small amount of additional compressed gas G1 is used for directly carrying out side extraction on partial ascending gas in the lower portion of a separation plate of the dividing-wall column, then the ascending gas is conveyed into the lower portion of the side extraction section, and the amount ofthe ascending gas in the side extraction section of the dividing-wall column is regulated; and in addition, the reflux liquid amount at the top of the side extraction section of the dividing-wall column is regulated and controlled by adjusting the reflux liquid amount of a liquid re-distributor of the side extraction section. According to the separation device for the dividing-wall column and theregulation and control method of the separation device, the regulation and control of the flow rate of the ascending gas and the reflux liquid of the side extraction section of the dividing-wall column are achieved. The device has the advantages of a simple structure, reduced resistance, easy operation and control and the like, the technical problem that gas-liquid two-phase regulation and control are difficult for separation units on the two sides of a separation plate of an existing dividing-wall column device is solved, and effective control is achieved.