The invention provides a harmless treatment and resource utilization method for sheep manure in a high-cold plateau of northwest Sichuan. The method includes the following steps: step A, preparing fermentation microorganisms and selecting functional bacteria; step B, preparing a fermentation microbial agent and a functional bacterial agent; step C, stacking the sheep manure; step D, adding the fermentation agent; step E, adding a nitrogen source; step F, performing fermentation on the sheep manure; and step G, adding the functional bacterial agent. Multiple microorganisms composed of mixing native yeasts, bacillus and lactobacillus screened in the high-cold plateau of the northwest Sichuan according to a certain ratio are efficient low-temperature active microbial fermentation microorganisms, can grow and reproduce rapidly under adverse conditions such as high cold and strong ultraviolet rays, and can be used for rapid biological fermentation of the sheep manure, so that the purpose ofharmless treatment of the sheep manure in the area is achieved.