The application discloses a region data acquisition and equipment control system and method for an IoT (Internet of Things). The control method disclosed by the application comprises the steps of: establishing a network connection between a mediation device and a control end; receiving device information of the mediation device, and by the control end, listing a virtual communication interface anda virtual access model according to the device information; setting far-end equipment of a virtual communication interface and enabling the far end equipment to correspond to terminal equipment; sending equipment commands to the far end equipment, and by the virtual access model, setting priorities of the equipment commands; converting the equipment commands into a network packet and sending thenetwork packet to the mediation device; by the mediation device, receiving the equipment commands, and distinguishing the priorities of the equipment commands; according to the priorities of the equipment commands, deciding a sequence of sending the equipment commands to the terminal equipment; by the terminal equipment, sending reply responses to the mediation device; and distinguishing priorities of the reply responses and deciding a sequence of sending the reply responses to the control end; and sending the reply responses to the control end.