The invention discloses an audio output method based on a vocal print. The method comprises the steps of when audio information is received, acquiring vocal print information in the audio information,finding a vocal print sample corresponding to the vocal print information in a vocal print database; judging whether an audio sample corresponding to the audio information exists in the audio database or not; if the audio sample corresponding to the audio information does not exist in the audio database, outputting a lip shape acquisition command to a video identification device to acquire a target lip shape; and generating a target audio according to the target lip shape and the vocal print sample, and outputting the target audio. The invention also discloses an audio output device and audiooutput equipment based on the vocal print, and a readable storage medium. According to the method, device, equipment and medium provided by the invention, audio playing quality is improved under theinfluence of surroundings and other uncontrollable factors.