The invention discloses an intelligent control system of transformers and coolers based on comprehensive perception and a working method thereof. Equipment operating conditions are comprehensively judged according to multi-information of the transformers and the coolers, a reliable identification method is provided for equipment states, real-time monitoring, early warning and evaluation of a wholecooling system are realized, and intelligent management of cooler operation is realized. According to the intelligent control system of the transformers and the coolers based on the comprehensive perception, feed-through transformers and air switches are arranged on connecting circuits of a power supply I, a power supply II and a bus bar; air switches are arranged on connection circuits of the bus bar and the coolers; the connection circuits of the bus bar and the coolers include main circuits and two branch circuits connected in parallel on the main circuits; air switches are installed on the main circuits, feed-through transformers are arranged on the two branch circuits correspondingly connected with an oil pump and a fan; and a transformer and cooler intelligent control device is further included, and the transformer and cooler intelligent control device comprises a central MCU, multiple sampling circuits and multiple voltage transformers.