The invention discloses a multi-target-oriented transformer substation optimization control method, which comprises the following steps of: 1) obtaining the priority of each bus of the transformer substation, and sequentially adjusting the voltage of each bus according to the priority of each bus so as to enable the voltage of each bus to be qualified, 2) correcting and controlling reactive powerand power factors of the high-voltage side gateway of the main transformer substation to enable the reactive power of the high-voltage side gateway of the main transformer substation to be qualified and enable the power factors of the high-voltage side gateway of the main transformer substation to be within a preset limit value range, and 3) performing voltage optimization on the 110kV bus on thehigh-voltage side of the main transformer substation to finish multi-target-oriented transformer substation optimization control. Thus, the method can realize optimization control of the transformer substation in a complex power grid.