The invention relates to the technical field of sand fixing, in particular to a preparation method of a highly pressure-resistant cellulose graft copolymerized sand-fixing material. The method comprises following steps: neutralizing acrylic acid by hydroxide to prepare an acrylic monomer solution, grafting a monomer with cellulose, and preparing the sand-fixing material through copolymerization under the action of a cross-linking agent, an initiator, sodium silicate and silica sol. According to the embodiment, high-polymer resin is used as a framework and endows the sand-fixing material with ultrahigh water absorption and retention capacity, and the cellulose is used as the grafting monomer, so that the water retention capacity of the sand-fixing material is improved while the sand-fixingmaterial is endowed with biodegradability. With addition of sodium silicate and silica sol, compressive strength of a sand-fixing layer of the sand-fixing material is effectively improved. The sand-fixing material has higher cohesion, pressure resistance, water absorption and retention capacity, water resisting property, degradability and water erosion resistance and has important practical value.