The invention discloses a regional power grid operation quality limit evaluation method. According to the method, economic operation indexes, voltage fluctuation indexes, fault frequency indexes, frequent operation indexes, service life loss indexes and the like of a regional power grid are established from remote measurement and remote signaling data of a power system and characteristics of primary and secondary equipment of the power grid, and the operation quality of the regional power grid is comprehensively evaluated. According to the method, through constructing a regional power grid steady-state simulation model (PSSM) based on PandaPower, various power data associated with the operation quality of the regional power grid is analyzed by combining an optimal power flow (OPF) method and a principal component analysis method, and comprehensive evaluation of the operation quality of the regional power grid is realized based on the current operation parameters of the system by usinga limit evaluation method.