The invention relates to a lurasidone hydrochloride tablet which is used for treating severe depression related to bipolar I disorder of pediatric patients and can realize rapid and complete drug release and a preparation process of the lurasidone hydrochloride tablet. The drug and a part of diluent are dissolved in a mixed solvent of an organic solvent and water, then the drug and the part of diluent are mixed with remaining auxiliary materials at a high speed, dried, granulated and tableted to obtain the lurasidone hydrochloride tablet. Compared with the prior art, the lurasidone hydrochloride tablet is simple in preparation process, low in energy consumption, rapid to release and good in release repeatability, and the preparation is stable after accelerated test.