The invention discloses a grid-reinforced intelligent paper folding composite material structure design method, and belongs to the technical field of composite material structure design. A grid-reinforced intelligent paper folding composite material structure comprises a paper folding base body with folding marks and a grid-reinforced shape memory rigid framework. The grid-reinforced intelligent paper folding composite material structure design method comprises the steps that the grid-reinforced shape memory rigid framework is laid on the paper folding base body with folding marks, and then the paper folding base body with the folding marks and the grid-reinforced shape memory rigid framework are bonded and compounded together by using a resin glue with a shape memory function. A grid-reinforced intelligent paper folding composite material designed by the grid-reinforced intelligent paper folding composite material structure design method is light in structural mass, reliable and controllable in folding and unfolding and high in configuration changing capacity, meanwhile, the bearing performance after unfolding can also be guaranteed, and the design requirement of a large-scale expandable structure can be well met. The grid-reinforced intelligent paper folding composite material structure design method provides an effective solution for innovative design of a large foldable structure, and can be applied to design of structures which requirements on light weight, reliable folding and unfolding and high bearing capacity after unfolding.