The invention discloses a chemical equipment dustproofing door. The chemical equipment dustproofing door comprises a base frame, an isolation layer, a filter layer, a sliding groove, an air curtain machine, a water storage box, an atomizer, a mist absorber, a movable door, a fixed frame and a movable plate, wherein the base frame is used for fixing the movable door and made of aluminum alloy; thesliding groove is embedded in a protruding block in the middle of the base frame; the movable door is mounted in the sliding groove; the isolation layer is arranged on the right side of the movable door and composed of the air curtain machine and the fixed frame; the fixed frame is mounted on the top of the base frame; the air curtain machine is mounted in the fixed frame; the filter layer is arranged on the left side of the movable door and composed of the atomizer, the mist absorber, the water storage box and the movable plate; the water storage box is mounted at the bottom of the base frame; the atomizer is mounted in the water storage box; the movable plate is arranged on the top of the water storage box; and the mist absorber is matched with the atomizer and arranged in a groove in the top of the base frame. According to the chemical equipment dustproofing door, dust in air is removed and isolated through an inner protection layer and an outer protection layer, the dust in the aircan be reduced to the minimum, and a barrier can be formed between a workshop and an outer passageway.