The invention discloses a sealing device and a pumping system with the same. The sealing device comprises a body, a first end cover, a second cover and cover sealing members, wherein the first end cover and the second end cover are arranged on the body in a spaced mode in the preset direction, the body, the first end cover and the second end cover can define an accommodating cavity for accommodating sealing filler, the peripheral wall surface of the containing cavity is provided with a material injection port, the first end cover is provided with a first perforated hole, and the second end cover is provided with a second perforated hole; and the cover sealing members can be movably arranged between the open position and the closed position, the cover members in the open position can avoidthe material injection port so as to open the material injection port, and the cover members in the closed position can cover the material injection port so as to close the material injection port. According to the sealing device, a polished rod is sealed by the sealing device, so that not only can the pumping system be continuously operated so as to improve the oil recovery efficiency of the pumping system, but also the maintenance difficulty can be reduced, and the maintenance operation is simplified.