The invention discloses an open hole packer staged fracturing string with accurate crack distribution and a use method. The open hole packer staged fracturing string comprises a main oil pipe, whereina plurality of sliding sleeves distributed at intervals are connected to the main oil pipe; a plurality of packer groups are further connected to the main oil pipe; the packer groups correspond to the sliding sleeves one to one; each packer group comprises two packers connected to the main oil pipe; and the two packers are connected to the two sides of the sliding sleeves respectively to clamp the corresponding sliding sleeves in the middle. The crack initiation position of a crack is limited through the packer groups, the ideal layout of the crack can be realized, the purpose of balanced transformation of a reservoir is achieved, the contact area between fracturing fluid and an open hole stratum can be remarkably reduced, the filtration loss of the fracturing fluid is effectively reduced, and the crack forming effect of the fracturing fluid is improved.