The present invention relates to the field of bio-production of metabolites, and in particular of metabolites produced by a microorganism using more particularly oxaloacetate as substrate or co-substrate upstream in the biosynthesis pathway. There is indeed a need in the art for transformed, in particular recombinant, microorganisms having at least an increased ability to produce oxaloacetate, thus allowing an increased capacity to produce oxaloacetate-derived amino acids and amino acid derivatives, said oxaloacetate-derived amino acids and amino acid derivatives being termed in the present text oxaloacetate derivatives. The solution proposed in the present invention is the use of a genetically modified yeast comprising many modifications as described in the present text.