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发明公开
CN111094981A PCT和PRO-ADM作为监测抗生素治疗的标记物 有权

PCT和PRO-ADM作为监测抗生素治疗的标记物
摘要：
本发明涉及一种在患有感染性疾病并接受一种或多种抗生素治疗的患者中进行抗生素治疗指导、分层和/或控制的方法。特别地，该方法包括从所述患者分离第一样品，在分离所述第一样品并开始抗生素治疗后从所述患者分离第二样品，测定所述第一样品和所述第二样品中降钙素原(PCT)或其片段的水平，以及测定至少第二样品中的肾上腺髓质素前体(proADM)或其片段的水平，其中在所述第一样品和第二样品中PCT或其片段的水平，以及在所述第二样品中proADM或其片段的水平，指示是否需要改变一种或多种抗生素治疗。在本发明的优选实施例中，该方法还包括测定所述第一样品和所述第二样品中proADM或其片段的水平。在本发明的优选实施例中，所述第一样品和第二样品之间proADM和PCT水平的变化指示需要改变或维持所述抗生素治疗。此外，本发明还涉及一种用于实施本发明方法的试剂盒。
摘要（英）：

The invention relates to a method for antibiotic therapy guidance, stratification and/or control in a patient suffering from an infectious disease and receiving treatment with one or more antibiotic agents. In particular, the method comprises isolating a first sample from said patient, isolating a second sample from said patient after isolating the first sample and initiating antibiotic treatment, determining levels of procalcitonin (PCT) or fragment(s) thereof in the first and the second sample, and determining a level of proadrenomedullin (proADM) or fragment(s) thereof in at least the second sample, wherein the levels of PCT or fragment(s) thereof in said first and second samples, and the level of pro ADM or fragment(s) thereof in the second sample, are indicative of whether a change in the treatment with one or more antibiotic agents is required. In a preferred embodiment of the invention, the method comprises additionally determining a level of pro ADM or fragment(s) thereof in the first and second samples. In a preferred embodiment of the invention changes in the pro ADM and PCT levels between the first and second samples indicate a need for changing or maintaining the antibiotic treatment. Furthermore, the invention also relates to a kit for carrying out the method of the present invention.

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