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CN112368262A 一种制备普瑞巴林中间体(R)-3-(氨甲酰甲基)-5-甲基己酸的方法 有权

一种制备普瑞巴林中间体(R)-3-(氨甲酰甲基)-5-甲基己酸的方法
摘要：
一种生物酶法制备普瑞巴林手性中间体(R)‑3‑(氨甲酰甲基)‑5‑甲基己酸的方法，具体方法是：首先，以化合物(Ⅰ)3‑异丁基戊二酸为原料与含氮试剂反应生成式化合物(Ⅱ)3‑异丁基戊二酰亚胺；然后，化合物(Ⅱ)在生物酶的作用下立体选择性开环，生成化合物(Ⅲ)(R)‑3‑(氨甲酰甲基)‑5‑甲基己酸：
摘要（英）：

A method for preparing a pregabalin chiral intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid by a biological enzyme method. In particular, the method comprises: reacting Compound (I) 3-isobutylglutaric acid, as a raw material, with a nitrogen-containing agent to produce Compound (II) 3-isobutylglutarimide; and performing stereoselective ring-opening of Compound (II) under the action of a biological enzyme to produce Compound (III) (R)-3-(carbamoylmethyl)-5-methylhexanoic acid.

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