利索-全球专利检索

  1. 登录
  2. 注册
发明授权
CN1300139C 2－氧－3－羟基－LSD的半抗原、免疫原、抗体和偶联物 失效 - 权利终止

2－氧－3－羟基－LSD的半抗原、免疫原、抗体和偶联物
摘要：
本发明描述了一种半抗原，其在2-氧-3-羟基-LSD的8β-羧酰胺的氮上用交联剂衍化而成。本发明也提供了一种免疫原，该免疫原包括上述半抗原和一个与半抗原结合的能够产生抗原性的载体材料；本发明还提供了一种含有上述半抗原的偶联物，其中的半抗原共价结合有一个可检测的标记物。另外，本发明涉及针对上述免疫原的抗体。最后，本发明涉及检测或测定生物体液中的2-氧-3-羟基-LSD的方法和试剂盒。本发明的抗体对2-氧-3-羟基-LSD具有高度的特异性，而与LSD和去甲-LSD无显著交叉反应。
摘要（英）：

The present invention provides a hapten derivatized with a monofunctional or a bifunctional crosslinker, either at the nitrogen of the 8 beta -carboxamide or at N-6, of 2-oxo-3-hydroxy-LSD. The present invention also provides an immunogen comprising the aforementioned hapten, coupled to an antigenicity-conferring carrier material, as well as, conjugates comprising the aforementioned hapten covalently bonded to a detectable labelling agent. In addition, the present invention concerns antibodies raised against the aforementioned immunogens. Finally, the present invention relates to methods and kits for detecting or determining LSD metabolites Ä2-oxo-3-hydroxy-LSD and N-desmethyl-LSD (nor-LSD)Ü in biological fluids. The antibodies of the present invention have broad specificity towards each of 2-oxo-3-hydroxy-LSD and nor-LSD.

公开/授权文献
0/0