The production method of bottled liquor with a whole pear in the interior of liquor bottle includes the following steps: cleaning liquor bottle, cutting bottle block, placing small pear into bottle, disinfecting fruit, injecting liquor and storage. Said inventino can make the pear fruit being in the interior of bottle grow under the environment isolating from exterior, and can protect the pear fruit being in the liquor bottle against various diseases of yellow mealworm, black heart and others, and can raise pear fruit setting ratio.