The use of a compound comprising formula (I), or a salt, ester, amide or prodrug thereof in the manufacture of a medicament for the treatment of obesity and related disorders; processes for preparing these compounds and pharmaceutical compositions containing them are disclosed, wherein A is an optionally substituted thienyl moiety, Y is O, S, or NR<2>, R<1> is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups and R<2> is hydrogen or a group as defined for R<1>.